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KMID : 0369820140440040237
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Jorunal of Korean Pharmaceutical Sciences
2014 Volume.44 No. 4 p.237 ~ p.242
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Aqueous carboxymethyl gum kondagogu as vehicle for ocular delivery
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Kumar Ashok
Ahuja Munish
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Abstract
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Aqueous solutions of carboxymethyl gum kondagogu (CMGK), an anionic bioadhesive polymer were evaluated as vehicles for ophthalmic delivery using tropicamide as a model drug. Aqueous ophthalmic solution of tropicamide (1 %, w/v) in CMGK (5 %, w/v) dispersions were formulated. The aqueous CMGK vehicle, formulated tropicamide eye drops and commercial tropicamide formulations were assessed comparatively for ex vivo ocular tolerance using hen’s egg chorioallantoic membrane assay. The results indicated ocular tolerability of aqueous CMGK vehicle. The results of comparative ex vivo corneal permeation study of tropicamide from the aqueous CMGK vehicle (5 %, w/v) conducted across isolated goat cornea revealed a no significant difference in the corneal permeation of tropicamide from the CMGK vehicle based formulation as compared to the commercial formulation. Further, the results of in vivo mydriatic response study conducted in rabbits revealed a non significant difference in the mydriatic response of tropicamide from the aqueous CMGK vehicle and commercial formulations. In conclusion, CMGK can be used as an ocularly tolerable polymer for formulating ophthalmic dosage forms.
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KEYWORD
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Carboxymethyl gum kondagogu, Ophthalmic vehicle, Tropicamide, HET-CAM assay, Mydriatic response, Corneal permeation
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